The goal of this research was to assess the impact of Myo-inositol on pregnancy success in infertile women candidates for IVF and ICSI in the Infertility Treatment Center, Besat hospital, Kurdistan University of Medical Sciences, Sanandaj, Iran. Several reports point to the possible role of inositol phospholipids-calcium in oocyte development (12, 13). The mechanisms of calcium release during oogenesis play an important role in the success of fertilization. Evidence suggests that this receptor channel has a key role in regulating calcium signaling in the oocytes of mammals (11). The inositol 1,4,5-triphosphate receptor channel is found in mammalian cells which are intracellular mediators for the release of calcium (9, 10). Studies on inositol and its isoforms (particularly Myo-inositol) in IVF have demonstrated that this molecule reduces insulin resistance and improves ovarian function, oocyte quality, and embryo pregnancy rates (8). Myo-inositol plays a key role in all aspects of cell physiology including lipid synthesis, cell morphogenesis, cell membrane structures, and cell membrane functions (6, 7). Myo-inositol is a C6 sugar alcohol belonging to the B-group vitamins (5). Antioxidants are compounds that can decrease oxidative damage in infertile women (4). The balance between the production and clearance of reactiveoxygen species is critical to the health of the female reproductive system. Using supplements in ARTs can be very helpful in increasing pregnancy rates (3). ![]() ![]() However, one of the most important problems of these methods is the low rate of pregnancy success (2).ĭespite significant advances in ARTs, there are still problems in achieving desirable results through IVF and ICSI techniques. IVF and ICSI are the most appropriate treatments in infertility clinics. In vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) are effective ARTs (1). Nowadays assisted reproductive techniques (ARTs) are used to achieve fertility in infertile people.
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